The carcinogenicity of some antimalarial drugs using the Egyptian toad Bufo regularis as a biological test animal.
Identifieur interne : 002E18 ( Main/Exploration ); précédent : 002E17; suivant : 002E19The carcinogenicity of some antimalarial drugs using the Egyptian toad Bufo regularis as a biological test animal.
Auteurs : M M El-Mofty [Égypte] ; V V Khudoley ; S A Sakr ; H S Abdel-GawadSource :
- Nutrition and cancer [ 0163-5581 ] ; 1992.
Descripteurs français
- KwdFr :
- Animaux, Antipaludiques (effets indésirables), Association médicamenteuse, Bufonidae, Chloroquine (effets indésirables), Femelle, Lymphome malin non hodgkinien (), Lymphome malin non hodgkinien (anatomopathologie), Modèles animaux de maladie humaine, Mâle, Primaquine (effets indésirables), Sarcome expérimental (), Sarcome expérimental (anatomopathologie), Tumeurs du foie (), Tumeurs du foie (anatomopathologie), Tumeurs du rein (), Tumeurs du rein (anatomopathologie).
- MESH :
- anatomopathologie : Lymphome malin non hodgkinien, Sarcome expérimental, Tumeurs du foie, Tumeurs du rein.
- effets indésirables : Antipaludiques, Chloroquine, Primaquine.
- Animaux, Association médicamenteuse, Bufonidae, Femelle, Lymphome malin non hodgkinien, Modèles animaux de maladie humaine, Mâle, Sarcome expérimental, Tumeurs du foie, Tumeurs du rein.
English descriptors
- KwdEn :
- Animals, Antimalarials (adverse effects), Bufonidae, Chloroquine (adverse effects), Disease Models, Animal, Drug Combinations, Female, Kidney Neoplasms (chemically induced), Kidney Neoplasms (pathology), Liver Neoplasms (chemically induced), Liver Neoplasms (pathology), Lymphoma, Non-Hodgkin (chemically induced), Lymphoma, Non-Hodgkin (pathology), Male, Primaquine (adverse effects), Sarcoma, Experimental (chemically induced), Sarcoma, Experimental (pathology).
- MESH :
- chemical , adverse effects : Antimalarials, Chloroquine, Primaquine.
- chemically induced : Kidney Neoplasms, Liver Neoplasms, Lymphoma, Non-Hodgkin, Sarcoma, Experimental.
- pathology : Kidney Neoplasms, Liver Neoplasms, Lymphoma, Non-Hodgkin, Sarcoma, Experimental.
- Animals, Bufonidae, Disease Models, Animal, Drug Combinations, Female, Male.
Abstract
Feeding Egyptian toads (Bufo regularis) with chloroquine and primaquine separately induced tumor formation in 14% and 19% of the animals, respectively. When chloroquine and primaquine were given in combination, the tumor incidence increased to 23.5%. Chloroquine feeding resulted in tumors located in the liver (lymphosarcomas) and primaquine in tumors in the kidney (histiocytic sarcomas). Toads fed chloroquine plus primaquine developed tumors in the liver, kidney, lung, and urinary bladder, and all the tumors were diagnosed as histiocytic sarcomas. It is speculated that one or more metabolites of chloroquine and primaquine (e.g., quinone) may be responsible for tumor induction in the toads.
DOI: 10.1080/01635589209514219
PubMed: 1437656
Affiliations:
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sort="Sakr, S A" uniqKey="Sakr S" first="S A" last="Sakr">S A Sakr</name></author><author><name sortKey="Abdel Gawad, H S" sort="Abdel Gawad, H S" uniqKey="Abdel Gawad H" first="H S" last="Abdel-Gawad">H S Abdel-Gawad</name></author></analytic><series><title level="j">Nutrition and cancer</title><idno type="ISSN">0163-5581</idno><imprint><date when="1992" type="published">1992</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antimalarials (adverse effects)</term><term>Bufonidae</term><term>Chloroquine (adverse effects)</term><term>Disease Models, Animal</term><term>Drug Combinations</term><term>Female</term><term>Kidney Neoplasms (chemically induced)</term><term>Kidney Neoplasms (pathology)</term><term>Liver Neoplasms (chemically induced)</term><term>Liver Neoplasms (pathology)</term><term>Lymphoma, Non-Hodgkin (chemically induced)</term><term>Lymphoma, Non-Hodgkin (pathology)</term><term>Male</term><term>Primaquine (adverse effects)</term><term>Sarcoma, Experimental (chemically induced)</term><term>Sarcoma, Experimental (pathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antipaludiques (effets indésirables)</term><term>Association médicamenteuse</term><term>Bufonidae</term><term>Chloroquine (effets indésirables)</term><term>Femelle</term><term>Lymphome malin non hodgkinien ()</term><term>Lymphome malin non hodgkinien (anatomopathologie)</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Primaquine (effets indésirables)</term><term>Sarcome expérimental ()</term><term>Sarcome expérimental (anatomopathologie)</term><term>Tumeurs du foie ()</term><term>Tumeurs du foie (anatomopathologie)</term><term>Tumeurs du rein ()</term><term>Tumeurs du rein (anatomopathologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antimalarials</term><term>Chloroquine</term><term>Primaquine</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Lymphome malin non hodgkinien</term><term>Sarcome expérimental</term><term>Tumeurs du foie</term><term>Tumeurs du rein</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Kidney Neoplasms</term><term>Liver Neoplasms</term><term>Lymphoma, Non-Hodgkin</term><term>Sarcoma, Experimental</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Antipaludiques</term><term>Chloroquine</term><term>Primaquine</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Kidney Neoplasms</term><term>Liver Neoplasms</term><term>Lymphoma, Non-Hodgkin</term><term>Sarcoma, Experimental</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Bufonidae</term><term>Disease Models, Animal</term><term>Drug Combinations</term><term>Female</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Association médicamenteuse</term><term>Bufonidae</term><term>Femelle</term><term>Lymphome malin non hodgkinien</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Sarcome expérimental</term><term>Tumeurs du foie</term><term>Tumeurs du rein</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Feeding Egyptian toads (Bufo regularis) with chloroquine and primaquine separately induced tumor formation in 14% and 19% of the animals, respectively. When chloroquine and primaquine were given in combination, the tumor incidence increased to 23.5%. Chloroquine feeding resulted in tumors located in the liver (lymphosarcomas) and primaquine in tumors in the kidney (histiocytic sarcomas). Toads fed chloroquine plus primaquine developed tumors in the liver, kidney, lung, and urinary bladder, and all the tumors were diagnosed as histiocytic sarcomas. It is speculated that one or more metabolites of chloroquine and primaquine (e.g., quinone) may be responsible for tumor induction in the toads.</div></front></TEI><affiliations><list><country><li>Égypte</li></country></list><tree><noCountry><name sortKey="Abdel Gawad, H S" sort="Abdel Gawad, H S" uniqKey="Abdel Gawad H" first="H S" last="Abdel-Gawad">H S Abdel-Gawad</name><name sortKey="Khudoley, V V" sort="Khudoley, V V" uniqKey="Khudoley V" first="V V" last="Khudoley">V V Khudoley</name><name sortKey="Sakr, S A" sort="Sakr, S A" uniqKey="Sakr S" first="S A" last="Sakr">S A Sakr</name></noCountry><country name="Égypte"><noRegion><name sortKey="El Mofty, M M" sort="El Mofty, M M" uniqKey="El Mofty M" first="M M" last="El-Mofty">M M El-Mofty</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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